Press Release

2009-12-03

Shaken Bioreactors Provide Culture Alternative

T. Anderlei, C. Cesana, C. Buerki, M. De Jesus, M. Kuehner, F. Wurm, R. Lohser

Genetic Engineering and Biotechnology News GEN (2009), Vol. 29, No. 19

The application of shaken bioreactors for cell cultivation has increased enormously in the last eight years. These bioreactors are used for the expression (transient and stable) of recombinant proteins in drug and diagnostic research. Extensive tests demonstrate their potential in terms of performance, flexibility, and cost-effectiveness when compared with more conventional technologies.

Shaken bioreactors are typically operated in a temperature-, CO2-, and humidity-controlled environment. For medium-scale work with volumes from 50 mL up to 1 L of culture medium, disposable Erlenmeyer flasks, both with small bottom baffles and without baffles, are most commonly used.

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