AAV process development
Our HEKExpress® cell host’s unique efficiency in producing AAV is the result of over twenty years of innovation and fine-tuning. The highlights:
High titers
— up to 1 × 1015 vg/L
Any serotype, any Gene of Interest
HEK293 cells in suspension adapted in ACF
Robust cells for scalable processes
— up to 40 L
cGMP compliant
— fully characterized MCB
What properties make HEKExpress® such an efficient cell host?
High viable cell densities
Over 107 cells/mL without feed
Fast doubling time
Under 24 hours
Absence of SV40 large T antigen
Very low aggregation in STR
Leading know-how in HEK process optimization
Your serotype and Gene of Interest are optimally expressed, and we provide the following: high AAV productivity, a scalable process ready for transfer and speed with high throughput screening.
DOE for process optimization at 10 mL scale
Bioreactor runs up to 40 L scale
Downstream process development, serotype-specific development
Analytics development (dPCR, SEC-MALS, DLS, thermal shift...)
Process optimization
2× Improvement in VCD Compared to Commercially Available HEK293
10× Improvement in Yield from AAV2-GoI Process Optimization
Producing your AAV with ExcellGene
Based in Switzerland, our team is passionate about two things: solid science, and you, the client!
Every project is customized to client needs and handled with a dedicated team.
Tap into a deep and pioneering understanding of HEK science and process science.
We’re deeply committed to achieving your milestones, timelines and target titers.
Download the PDF
For your convenience, this overview of our AAV process development services is available as a downloadable PDF.
