Careers

ExcellGene is a privately owned contract research, development and manufacturing organization (CDMO) based in Monthey, Switzerland. ExcellGene’s unique transient and stable protein expression technologies together with extensive knowledge and experience in the biotech field cover broad value chain for its clients: from DNA construction and transfection to bioprocess development of scalable and GMP-compliant protein production processes. ExcellGene’s technology is one of the most advanced for rapid production of recombinant proteins and up to several grams of product delivered within weeks.

Available roles


Manufacturing/Engineering Specialist

Posted 30th March 2021

This position is permanent and full-time, and to start immediately.

Job description

Performing production-related tasks as assigned by the group lead. These tasks can include, but are not limited to, manufacturing tasks, quality tasks, facilities maintenance requirements, ordering of supplies, materials, and equipment for production.

The position is divided in the following fields of activities:

Manufacturing

The Manufacturing Specialist will support the cGMP cell banking unit with the planning and execution of all process steps of mammalian cell banking manufacturing from cell culture to filling including viability studies for cell banks. In cell banking he/she will be in the lead for preparation of master and working cell banks.

Engineering

The Engineering Specialist will support the installation, operation, maintenance and/or troubleshooting of manufacturing equipment such as washers, autoclaves, incubators, microbiological safety cabinets, ultracold freezers etc. He/She develops Standard Operating Procedures, Preventive Maintenance plans, calibration procedures, process descriptions and validation testing plans as requested. Monitor and control maintenance operations to achieve the targeted turn-around time within required quality standards.

Additional tasks include:

  • Supporting the team in the implementation and application of Quality Management System.
  • Evaluating test results, reviewing production documentation, working on deviations, change requests, supports risk assessments and the implementation of CAPAs (Corrective And Preventive Actions) to ensure high-quality GMP standards.
  • Creating documentation for each task, including manufacturing process, aseptic processing techniques, Good Manufacturing Practices (GMP), cleaning procedures and clean room safety practices and procedures.
  • Improvement of the MCB documentation (method and SOPs, records, validation and verification procedures for existing methods).
  • Implementation/support for implementation of diverse new or improved systems within cell banking, wherever applicable.
  • Assist in training new and existing employees on the cell banking unit.
  • Assist in providing positive and constructive individual feedback and building teamwork.

Required skills

  • Relevant hands-on experience in mammalian cell culture and cell banking activities under cGMP.
  • Good technical understanding of manufacturing processes and associated equipment.
  • General knowledge of clean room practices and familiarity with Current Good Manufacturing Practices (cGMP) preferred
  • Experience in maintenance of building management system preferred.
  • Accountable for assisting in the identification, development, and implementation of new systems which enhances the operation and/or engineering processes.
  • Must be aware of requirement specifications from an equipment qualification perspective (IC/OC, IQ/OQ, CRs, etc.)
  • Good knowledge and interpretation of cGMP, ISO, FDA, MHRA and Pharmacopeia requirements, and good documentation practices.
  • Capacity to establish written documentation on procedures, results, observations, including reports and documents that are required for regulatory purposes.
  • Experience in writing and/or revising SOP’s, batch records, and other Quality/Compliance related documents.
  • Strong interpersonal and leadership skills and abilities to drive projects towards completion under time and resources constrains.
  • Structured, focused and well-organized working attitude.
  • Must be detail-oriented with an ability to set priorities, and organize daily work requirements
  • Open-minded for new ideas and suggestions
  • Organizational and problem-solving skills, attention to detail and autonomy.
  • With strong sense of discipline and with initiative with hands-on approach to work.
  • Good communication skills.
  • Generally independent, but with ability to work in teams.
  • Fluency in English, oral French is plus.
  • Understanding of MS Office applications.

Mandatory requirements

  • Educational background required: Bachelor or Master Degree in biotechnology, biochemistry, life sciences or related discipline.
  • 1-3 years of experience with mammalian cell culture.
  • 1-3 years of supervisory/management experience, having a sound knowledge of aseptic processing, cell culture, engineering and compliance with GMP rules.
  • Ability to work in a time driven environment and to manage multiple priorities.
Apply for this position

[2×] Research Associate - Cell Line Development (Biologics)

Posted 19th March 2021

This position is permanent and full-time, and to start immediately.

Job description

  • Plan and perform cell culture activities with suspension-adapted mammalian cell lines, CHO and HEK:
    • Seed maintenance and expansion;
    • transfection for protein production and stable pool generation;
    • recombinant pool selection;
    • stable cell line generation and optimization;
    • batch and fed-batch cultures in non-instrumented small-scale bioreactors.
  • Design and conduct experiments, data analysis and presentation internally and to external clients
  • Provide support to Head of Cell Line Development (if needed)
  • Keep an up-to-date written and electronic record of executed laboratory work
  • Prepare project progress reports in form of PPT and final project report
  • This position is to report to Head of Cell Line Development

Required skills

  • Hands-on experience in mammalian cell culture, as well as protein production from mammalian cells (transient and/or stable)
  • Molecular biology skills are a plus
  • Understanding of MS Office applications
  • Organizational and problem-solving skills, attention to detail and autonomy
  • Strong sense of discipline and initiative with hands-on approach to work
  • Good communication skills
  • Generally independent, but with ability to work in teams
  • Fluency in English, oral French is a plus.

Mandatory requirements

  • Educational background required: Bachelor or Master Degree in biotechnology, biochemistry, molecular biology or related discipline.
  • 1-3 years of experience with mammalian cell culture.
Apply for this position

[2×] Lab Technician - Cell Culture (Biologics)

Updated 19th March 2021

In order to support our cell culture activities, we are looking for two Lab Technicians - Cell Culture (Biologics).

Job description

  • Plan and perform cell culture techniques with suspension-adapted mammalian cell lines (e.g. CHO and HEK): seed maintenance and expansion, transfection for protein production and stable pool generation, recombinant pool selection, stable cell line generation and optimization; batch and fed-batch cultures
  • Perform general laboratory tasks: handling of stocks and ordering, preparation of reagents, and maintain the functionality of equipment
  • Conduct experiments and provide support as defined by the Project Team Leader
  • Keep an up-to-date written and electronic record of your laboratory work
  • Support the preparation of process development report and presentations.

Required skills

  • Hands-on experience in mammalian cell culture, as well as protein production from mammalian cells (transient and/or stable)
  • Molecular biology skills are a plus
  • Understanding of MS Office applications
  • Organizational and problem-solving skills, attention to detail and autonomy
  • With strong sense of discipline and with initiative with hands-on approach to work
  • Good communication skills
  • Generally independent, but with ability to work in teams
  • Fluency in French, oral English is a plus.

Mandatory requirements

  • Educational background required: from technical (“CFC Laborantin”) to Bachelor Degree in biotechnology, biochemistry, molecular biology or related discipline
  • 1-3 years of relevant laboratory experience.
Apply for this position

[2×] Technicien de laboratoire – Culture cellulaire (produits biologiques)

Mis à jour le 19 Mars 2021

ExcellGene est une entreprise privée de recherche, de développement et de fabrication de produits biologiques sous contrat (CDMO) basée à Monthey, en Suisse. Les technologies uniques d’expression de protéines transitoires et stables d’ExcellGene, associées à son expérience et ses connaissances approfondies dans le domaine de la biotechnologie, lui permettent de réaliser les prestations suivantes pour ses clients : de la construction et de la transfection d’ADN au développement de bioprocédés de production de protéines évolutifs et conformes aux BPF. La technologie d'ExcellGene est l'une des plus avancées pour la production rapide de protéines recombinantes et jusqu'à plusieurs grammes de produits biologiques peuvent être livrés en quelques semaines.

Afin de soutenir les activités de culture cellulaire, ExcellGene recherche activement un(e): Technicien de laboratoire – Culture cellulaire (produits biologiques). Ce poste est fixe, à temps plein, et à pourvoir immédiatement.

Déscription du poste

  • Planifier et réaliser des activités de culture cellulaire avec des lignées cellulaires de mammifères en suspension (CHO et HEK) : Maintien et amplification de cultures cellulaires, transfection pour la production de protéine et la génération de pool stable, sélection de pool de cellules, génération et optimisation de lignées cellulaires stables, cultures batch et fed-batch non instrumentées à petite échelle.
  • Effectuer des tâches générales de laboratoire: gestion des stocks et commande, préparation des réactifs et effectuer la maintenance et l’entretien des équipements.
  • Mener des expériences et fournir un soutien tel que défini par le chef d'équipe du projet.
  • Reporter et tenir à jour les travaux de laboratoire exécutés sous forme écrite et électronique
  • Participer à la préparation du rapport de développement final et des présentations

Compétences requises

  • Expérience pratique en culture de cellules de mammifères, ainsi qu’en production de protéines recombinantes en cellules de mammifères (transitoire et/ou stable)
  • Compétences en biologie moléculaire, un plus
  • Connaissance des logiciels MS Office
  • Sens de l’organisation et de la résolution de problèmes, souci du détail et autonomie
  • Sens aigu de la discipline et prise d'initiative avec une approche pratique du travail
  • Bonnes aptitudes à communiquer
  • Généralement indépendant, mais capable de travailler en équipe
  • Maîtrise du français, communication orale en anglais un plus

Formation requise

  • Diplôme de technicien de laboratoire (“CFC Laborantin”), Bachelor en biotechnologie, biochimie, biologie moléculaire ou équivalent
  • 1 à 3 ans d'expérience pertinente en laboratoire.
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Submit a speculative application!

Posted 11th November 2020

We are now actively searching for exceptional individuals with high ethical standards that strive for scientific and technological excellence within a creative and team-oriented work environment. If this sounds interesting to you, we highly encourage you to send us your application through the form below, and ticking the box for 'speculative application'.

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